A plant alkaloid called berberine has been used in traditional Chinese medicine to treat a wide range of illnesses for hundreds of years. Recently, it has gained popularity as a weight loss supplement. In this article, we will explore the effectiveness of berberine for weight loss and its potential health benefits.

What is Berberine?

Berberine is a compound found in several plants, including Oregon grape, barberry, and goldenseal. It has been used in traditional Chinese medicine for centuries to treat diarrhea, infections, and other conditions. 

Modern research has shown that berberine may have health benefits beyond its traditional uses. For example, it may help people lose weight, control their blood sugar better, and reduce inflammation. Berberine is available in various forms, including capsules, soft gels, tablets, liquid, and powder. However, it is important to note that berberine supplements may cause side effects, such as upset stomach and nausea, and should not be used as a replacement for approved medical therapies.

Overall, berberine shows promise as a natural health supplement, but it is important to talk to a doctor before using it and keep a close eye out for any possible side effects.

How Does Berberine Work for Weight Loss?

Berberine has been shown to affect several metabolic pathways that can contribute to weight loss. It can turn on AMPK, an enzyme that controls how energy is used and makes muscles take in more glucose. This can lead to increased insulin sensitivity and decreased fat accumulation.

Berberine may work for weight loss in several ways. It has been shown to lower blood sugar levels and increase weight loss. Berberine enhances brown fat in the body, which helps increase body temperature, burn more fat, and increase baseline metabolism.

It can also help regulate lipid metabolism and lower levels of triglycerides and cholesterol, which makes it easier for people to lose weight and get over weight loss resistance.

Berberine also helps to keep the gut microbiome in balance by controlling bacteria and encouraging the body’s cells to get rid of waste. Weight gain can be caused by an unbalanced gut microbiome, which berberine may be able to fix. Finally, berberine has been studied for its potential effects in controlling an irregular heartbeat, lowering lipid levels, blood pressure, and blood sugar levels, which may also contribute to its potential as a weight loss supplement.

Research on Berberine and Weight Loss

Berberine has been the subject of several studies examining its effects on weight loss. In one 12-week study, overweight participants who took 500 mg of berberine three times a day lost an average of 5 pounds, while the placebo group gained an average of 1 pound [1]. Another study found that berberine can decrease body weight, BMI, and waist circumference in obese individuals [2].

Berberine has also been shown to improve insulin sensitivity, which can help regulate blood glucose metabolism and reduce the risk of developing type 2 diabetes. Improved insulin sensitivity can also help reduce the accumulation of body fat [2].

Excited Girl Wearing Too Big Jeans After Weight Loss Indoor

Also, berberine has been shown to increase the number of mitochondria in muscle mass. This may speed up the metabolism and make the mitochondria work better overall. This boost to the metabolism helps promote weight loss [4].

In a comparison with metformin, a medication commonly prescribed to treat metabolic syndrome and type 2 diabetes, women with PCOS taking berberine had better insulin and glucose control and even saw more significant drops in body fat [3]. However, much of the research on the weight loss effects of berberine has been done in mice and rats [2].

Overall, berberine may help you lose weight, but its effects may not be very big, and people who don’t have problems with their blood sugar may not even notice [5]. Before starting to take berberine for weight loss or any other reason, it is important to talk to a doctor or other health professional.

Other Potential Health Benefits of Berberine

In addition to weight loss, berberine has been shown to have several other potential health benefits. It can lower blood sugar levels, improve cholesterol levels, and reduce inflammation. It may also have antimicrobial and anticancer properties.

How to Take Berberine for Weight Loss

Berberine supplements are available in various forms, including capsules, tablets, and powders. The recommended dosage for weight loss is 500 mg to 1500 mg per day, taken in divided doses with meals. It is important to choose a high-quality supplement from a reputable manufacturer.

6. Side Effects of Berberine

Berberine is generally considered safe when taken at recommended dosages. However, it can cause gastrointestinal side effects, such as diarrhea, constipation, and stomach pain. It may also interact with certain medications, including blood thinners, antidepressants, and statins.

7. Precautions and Interactions

Women who are breastfeeding or pregnant shouldn’t use berberine. It may also interact with other herbs and supplements, including garlic, ginseng, and milk thistle. It is important to talk to your healthcare provider before taking berberine, especially if you have a medical condition or are taking medications.


No, berberine has been shown to help people lose weight by turning on AMPK, making insulin more sensitive, and stopping fat from building up.

Even though berberine is thought to be safe for most people, it can cause stomach upset and diarrhea in some people. It’s important to speak with a healthcare professional before starting any new supplement, especially if you have any underlying health conditions or are taking medication.

The best amount of berberine to take for weight loss depends on the person and their health needs. It’s best to follow the dosing instructions on the supplement label or as directed by a healthcare professional.

Research has shown that berberine may help reduce belly fat as well as overall body weight. But more research is needed to confirm these effects and figure out the best dosage and length of time to take supplements.

It’s important to speak with a healthcare professional before combining berberine with other weight loss supplements, as they may interact and cause unwanted side effects.

Even though berberine may help you lose weight, it’s important to eat well and exercise regularly if you want your weight loss to be healthy and last. Berberine should be viewed as a complementary tool to support a healthy lifestyle.


Berberine is a promising supplement for weight loss, with several studies showing its effectiveness. It may also have other potential health benefits, such as improving blood sugar and cholesterol levels. However, it is important to take it under the guidance of a healthcare provider and to be aware of potential side effects and interactions.